Chemical name: Methanimidamide, N'-(4-chloro-2-methylphenyl)-N,N-dimethyl- Final regulatory action has been taken for the category: Pesticide Final regulatory action: The chemical is Banned Use or uses prohibited by the final regulatory action: pesticide is banned for use Pesticide use or uses that remain allowed: Prohibited for use as a pesticide The final regulatory action was based on a risk or hazard evaluation: Yes Summary of the final regulatory action: Banned by decree of former USSR Ministry of Health The reasons for the final regulatory action were relevant to: Human health and environment Summary of known hazards and risks to human health: chlordimeform and its principal metabolites are considered probable human carcinogens. Studies in mice indicate dose-related increased incidence of hemangisarcomas and hemangiomas malignant tumours of the blood vessels. These data are reinforced by human monitoring data which link a chlordimeform metabolite 4-chloro-o-toluidine (5-CAT), with bladder cancer. The primary concern is for plant manufacturing and agricultural workers handling or applying the insecticide who are subject to exposure to resisdues over several years. Animal data indicating carcinogenic potential are reinforced by human urine monitoring data which implicate a chlordimeform metabolite with bladder cancer. Expected effect of the final regulatory action in relation to human health: Reduction and stop of hazards and risks to human health Summary of known hazards and risks to the environment: Toxic to fish and wildlife. Relatively non-toxic to honey bees. Although data are not adequate, chlordimeform and its HCL salts are considered to have little potential for leaching to ground-water. They are relatively immobile in mulch and loam soils and short lived. Residues may move from a treated site in run-off sediment. Expected effect of the final regulatory action in relation to the environment: Reduction of hazards and risks to environment. Date of entry into force of the final regulatory action: 01/01/1978 |